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KMID : 0357920010350040314
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Korean Journal of Pathology
2001 Volume.35 No. 4 p.314 ~ p.318
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Preferential Expression of CD44 in Thyroid Papillary Carcinoma
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Kim Jung-Yeon
Yoo Jin-Ye
Cho Hye-Jae
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Abstract
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Background: Papillary carcinoma is one of the most common malignant thyroid tumors and an important prognostic factor is the lymph node status. CD44 is a cell adhesion molecule and is associated with metastasis. The purpose of this study was to discover whether CD44 is valuable in the diagnosis of the papillary carcinoma, and whether Ki-67 and p53 are correlated with CD44 in the papillary carcinoma.
Methods: We studied CD44, Ki-67 and p53 expressions in 34 cases of formalin-fixed paraffin embedded papillary thyroid carcinomas, and 20 cases of the follicular neoplasm using mouse anti-CD44 （H-CAM）, Ki-67 and p53 monoclonal antibodies.
Results: Most of the papillary carcinomas expressed diffuse and intense membrane staining of CD44 （32/34 cases, 94.1％）. Focal scattered immunoreactivity was observed in the ofllcular neoplasm （8/20 cases, 40.0％）. The staining pattem1s of CD44 were similar in both follicular adenoma and carcinoma. Both groups with or without lympy node metastasis showed similar expression paftems for CD44. There were no differences in Ki-67 and p53 staining between papillary carcinomas and follicular neoplasms.
Conclusions: The result shows that papillary carcinomas preferentially display the CD44 antigen, and it is a useful diagnostic tool in the equivocal cases. There is no correlation among CD44, Ki-67 and p53 expressions in the papillary carcinoma.
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KEYWORD
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Thyroid, Carcinoma, Papillary, Follicular, CD44 antigen
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